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Physical Biosciences Division
Physical Biosciences Division
At the crossroads of chemical engineering, chemistry, physics, and biophysics, Arup Chakraborty probes the subtle workings of the immune system. Using sophisticated theoretical and computational methods developed in his lab to study this and other complex systems, Chakraborty reports in Nature Immunology how he developed a molecular model describing how CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse. Read the Nature article here
Computing resources at Berkeley Lab's NERSC
Understanding how cells respond to external stimuli is an important goal in biology. The response to external stimuli is the result of interactions between many cellular components, and the spatio-temporal evolution of these components can now be vividly observed in imaging experiments. However, it is difficult to intuit the mechanistic underpinnings of phenomena from these observations alone. This is because the observed complexity emerges from collective dynamics of the many interacting cellular components. The goal of our program is to develop multiscale theoretical and computational approaches that serve as full partners of genetic and biochemical experiments in the discovery process in cell biology. To take steps toward this goal, we are currently studying various aspects of T lymphocyte activation and the behavior of some eukaryotic cells using synergistic computational studies and genetic, biochemical, and imaging experiments. Understanding these systems is of direct relevance to biomedicine and energy related technological applications.
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At the crossroads of chemical engineering, chemistry and physics

Arup Chakraborty named Department Head

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More highlights from Computational and Theoretical Biology

Arup ChakrabortyArup Chakraborty new Department Head of Theoretical and Computational Biology
In December 2003, Division Director Graham Fleming named Arup Chakraborty to head the reorganized Computational and Theoretical Biology Department. Chakraborty will lead the division's efforts to develop new computational strategies to analyze and predict solutions to biological problems. Division Director Graham Fleming said that "Chakraborty's distinguished research in areas as disparate as inter-cellular communication in the immune system and polymer science brings a bold and broad perspective to the rapidly growing demands of theoretical biology." Chakraborty serves as the Warren and Katherine Schlinger Distinguished Professor of Chemical Engineering and Professor of Chemistry, and the Chair of Chemical Engineering at UC Berkeley.

In February 2004, Arup Chakraborty was elected to the National Academy of Engineering (NAE) for his accomplishments in applying theoretical chemistry to practical problems in immune system recognition, polymer interfaces, sensor technology, and catalysis. Election to the National Academy of Engineering is among the highest professional distinctions accorded to an engineer. Academy membership honors those who have made "important contributions to engineering theory and practice, including significant contributions to the literature of engineering theory and practice," and those who have demonstrated accomplishment in "the pioneering of new fields of engineering, making major advancements in traditional fields of engineering, or developing/implementing innovative approaches to engineering education." "I am very pleased to be recognized by the National Academy," said Chakraborty. "It reflects the wonderful environment for doing research at Berkeley Lab and the campus."

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