Contact info
University of California, Berkeley
Department of Chemistry
Berkeley, California 94720-1460
USA

Location: 813A Latimer/Hildebrand
Phone: (510) 643-1682
Lab Phones: (510) 643-2223/-8889
Fax: (510) 642-836
Email: bertozzi@cchem.berkeley.edu
Web site: Bertozzi Lab

Research emphasis
Carolyn Bertozzi's research group studies cell surface interactions that contribute to human health and disease with specific projects in the areas of cancer, inflammation and bacterial infection. They use the techniques of organic synthesis, genetics and biochemistry as tools to study and manipulate complex cellular processes. Much of their research involves cell surface oligosaccharides, biopolymers that contribute to cell surface recognition and cell-cell communication, and that pose challenging synthetic targets. The biology of these structures, which are found as common posttranslational modifications of cell surface proteins, has attracted increasing attention since the initial sequence of the human genome was reported. Genome comparisons have revealed that the human genome is not much larger than those of lower organisms, but vastly more abundant in posttranslational machinery, accounting for numerous complex functions found only in mammals.

Professor Bertozzi is the Head of the Chemical Biology Department within the Physical Biosciences Division. Her efforts focus on developing high-throughput screening capabilities for small molecule based functional genomics research at LBNL.

Publications